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Generating Mature Cardiomyocytes from Stem Cells with Genetic Engineering
Cardiomyocytes can be generated in vitro with high throughput and quality at a clinically relevant scale using pluripotent stem cells. However, these cardiomyocytes are phenotypically similar to ones at early fetal stage and often lack the attributes of adult or mature cardiomyocytes which are desirable for drug screening, modelling of adult onset diseases...
Published: 2/18/2025
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Inventor(s): Emilia Entcheva, Julie Han
Keywords(s):
Category(s): Technology Classifications > Research Tools > Molecular Engineering, Technology Classifications > Therapeutics > Cells, Technology Classifications > Medical Devices > Regenerative Medicine
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High Throughput Microfluidic Perfusion Bioreactor
Bioreactors are usually used to control the growth of microorganisms or cells for pharmaceutical research and drug development. However, no bioreactor currently available in the market can provide in vivo-like conditions in a high throughput standard microtiter format. Moreover, they require significant modifications of the well-plate to achieve perfusion...
Published: 2/18/2025
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Inventor(s): Zhenyu Li, Lai Wei, David McLeod, Emilia Entcheva, Weizhen Li, Matthew Kay
Keywords(s):
Category(s): Technology Classifications > Research Tools
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High-throughput cardiotoxicity screening of drugs using optical dynamic clamp (ODC)
Cardiotoxicity is a major contributor to drug failure during clinical trials and drug withdrawal from the market. For this reason, new drugs must be screened for cardiotoxicity. High-throughput screening can eliminate unsafe drugs very early in a drug development program, so methods of accurate high-throughput cardiotoxicity screening are very desirable....
Published: 2/18/2025
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Inventor(s): David J. CHRISTINI, Trine KROGH-MADSEN, Emilia Entcheva, Bonnie Quach
Keywords(s):
Category(s): Technology Classifications, Technology Classifications > Research Tools > Drug Screening
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3D Biophotonic Devices for All Optical Electrophysiology
Optical actuation and sensing methods were demonstrated by GW for high-throughput drug and cardiotoxicity screening. However, modification of target cells takes time, has variable yield and can cause potential interference with cell’s innate functional responses.
GW researchers manufactured “spark-cell” spheroids, used as a reagent...
Published: 2/18/2025
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Inventor(s): Emilia Entcheva, Christianne Chua
Keywords(s):
Category(s): Technology Classifications > Research Tools > Drug Screening
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PMU-Embedded Analytics for Online Event Detection and Classification in Power Grids
The energy requirement of the world is increasing exponentially every year. With the power demand sites concentrated in the region with the highest population density, energy production sites must be located remotely. This isolation requires lengthy and complicated grids to be designed and manufactured to transmit power over long distances. Grid failures...
Published: 2/18/2025
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Inventor(s): Payman Dehghanian, Shiyuan Wang, Li Li
Keywords(s):
Category(s): Technology Classifications > Industrial or Consumer Tech > Energy Infrastructure and Environment
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High-Throughput All-Optical Cardiac Electrophysiology System
The withdrawal of drugs from the market is a costly consequence of undetected adverse effects or toxicity. Over 30% of such withdrawals are due to cardiac toxicity (pro-arrhythmic effects mediated by cardiac ion channels), therefore regulatory agreements mandate the testing of all new drugs for cardiac liability.
GW researchers developed the first...
Published: 2/18/2025
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Inventor(s): Emilia Entcheva, Aleksandra Klimas
Keywords(s):
Category(s): Technology Classifications > Research Tools > Drug Screening
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