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A Novel Selective HDAC11 Inhibitor with Broad Anti-Cancer Efficacy
HDAC11 is a Histone Deacetylase (HDAC) enzyme. However, HDAC11 has a high defatty-acylase activity while its deacetylation activity is virtually nonexistent, which is linked to poor prognosis in multiple cancers. This suggests that inhibition of HDAC11 can be used to treat cancers by modulating protein function. No potent and selective inhibitors for...
Published: 3/13/2025
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Inventor(s): Edward Seto, Hening Lin
Keywords(s):
Category(s): Technology Classifications > Therapeutics
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A Small Molecule Inhibitor Selective for HDAC11
HDAC11 is an enzyme which belongs to the Histone Deacetylase (HDAC) class of enzymes. However, HDAC11 has a high defatty-acylase activity while its deacetylation activity is virtually nonexistent. The defatty-acylase activity of HDAC11 is linked to increased interferon I signaling, suggesting that inhibition of HDAC11 can be used to treat diseases by...
Published: 2/18/2025
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Inventor(s): Edward Seto, Hening Lin, Thanh Ho
Keywords(s):
Category(s): Technology Classifications > Therapeutics > Small Molecules
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Self-neutralizing air-breathing thruster and method of neutralization
An ion-engine is the cutting edge for atmospheric air-breathing engines. The technology depends on ionizing and neutralizing atmospheric air particles which create thrust. This unique possibility makes it an ideal choice for very-low-orbit satellites. Very- low-orbit satellite capabilities have benefits such as higher resolution for images, weight...
Published: 2/18/2025
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Inventor(s): Michael Keidar, Anmol Taploo, Li Lin
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Category(s): Technology Classifications > Computers Electronics & Software, Technology Classifications > Computers Electronics & Software > Aviation, Technology Classifications > Industrial or Consumer Tech > Energy Infrastructure and Environment, Technology Classifications > Industrial or Consumer Tech > Industrial Manufacturing
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Non-Invasive Plasma Discharge Tube Device for Treating Brain Tumors
Treating brain tumors, like glioblastoma, is challenging. Current glioblastoma drugs, Rapamycin and Temozolomide (TMZ), generally only extend life for a matter of months, are not very effective in treating recurring tumors, and have significant clinical toxicity. A novel Plasma Discharge Tube (PDT) device has the potential to be more effective and less...
Published: 2/18/2025
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Inventor(s): Michael Keidar, Li Lin, Vikas Soni, Xiaoliang Yao, Dayun Yan, Jonathan Sherman
Keywords(s):
Category(s): Technology Classifications > Medical Devices, Technology Classifications > Medical Devices > Surgical
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PMU-Embedded Analytics for Online Event Detection and Classification in Power Grids
The energy requirement of the world is increasing exponentially every year. With the power demand sites concentrated in the region with the highest population density, energy production sites must be located remotely. This isolation requires lengthy and complicated grids to be designed and manufactured to transmit power over long distances. Grid failures...
Published: 2/18/2025
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Inventor(s): Payman Dehghanian, Shiyuan Wang, Li Li
Keywords(s):
Category(s): Technology Classifications > Industrial or Consumer Tech > Energy Infrastructure and Environment
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Cold atmospheric plasma-stimulated media for treating cancers
For successful cancer therapy, the most important aspect is selective eradication of cancer cells without damaging healthy cells. Cancer cells and normal cells have different thresholds for tolerance of reactive oxygen species (ROS) and reactive nitrogen species (RNS) before cell death (apoptosis) is induced. Previously, GW researchers invented a cold...
Published: 2/18/2025
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Inventor(s): Michael Keidar, Zhitong Chen, Xiaoqian Cheng, Li Lin
Keywords(s):
Category(s): Technology Classifications > Therapeutics > Cells, Technology Classifications > Therapeutics
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