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Potent And-1 Inhibitors that Suppress Tumor Growth and Overcome Platinum Drug Resistance

Ovarian cancer (OC) is one of the leading causes of cancer-related deaths in women. The survival rate of ovarian cancer patients is low largely due to platinum-based chemotherapy resistance and lack of alternative regimens. Recent studies showed that the Acidic nucleoplasmic DNA-binding protein 1 (And-1) activation promotes platinum drug resistance...

Published: 2/18/2025 | Inventor(s): Wenge Zhu, Yiliang Li, Jing Li

Keywords(s):

Category(s): Technology Classifications > Therapeutics > Small Molecules

SENP1 Enzymatic Activity Inhibitors for Platinum Resistant Ovarian Cancer

Ovarian cancer is one of the leading causes of cancer-related deaths in women. The survival rate of ovarian cancer patients is low largely due to platinum-based chemotherapy resistance and lack of alternative regimens. A recent study indicated that Janus tyrosine kinase 2 (JAK2), which activates the signal transducers and activators of transcription...

Published: 2/18/2025 | Inventor(s): Wenge Zhu, Jing Li, Ruiqin Wu, Yiliang Li

Keywords(s):

Category(s): Technology Classifications > Therapeutics > Small Molecules

PMU-Embedded Analytics for Online Event Detection and Classification in Power Grids

The energy requirement of the world is increasing exponentially every year. With the power demand sites concentrated in the region with the highest population density, energy production sites must be located remotely. This isolation requires lengthy and complicated grids to be designed and manufactured to transmit power over long distances. Grid failures...

Published: 2/18/2025 | Inventor(s): Payman Dehghanian, Shiyuan Wang, Li Li

Keywords(s):

Category(s): Technology Classifications > Industrial or Consumer Tech > Energy Infrastructure and Environment