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High-throughput cardiotoxicity screening of drugs using optical dynamic clamp (ODC)
Cardiotoxicity is a major contributor to drug failure during clinical trials and drug withdrawal from the market. For this reason, new drugs must be screened for cardiotoxicity. High-throughput screening can eliminate unsafe drugs very early in a drug development program, so methods of accurate high-throughput cardiotoxicity screening are very desirable....
Published: 5/12/2026
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Inventor(s): David J. CHRISTINI, Trine KROGH-MADSEN, Emilia Entcheva, Bonnie Quach
Keywords(s):
Category(s): Technology Classifications, Technology Classifications > Research Tools > Drug Screening
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3D Biophotonic Devices for All Optical Electrophysiology
Optical actuation and sensing methods were demonstrated by GW for high-throughput drug and cardiotoxicity screening. However, modification of target cells takes time, has variable yield and can cause potential interference with cell’s innate functional responses.
GW researchers manufactured “spark-cell” spheroids, used as a reagent...
Published: 5/12/2026
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Inventor(s): Emilia Entcheva, Christianne Chua
Keywords(s):
Category(s): Technology Classifications > Research Tools > Drug Screening
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High-Throughput All-Optical Cardiac Electrophysiology System
The withdrawal of drugs from the market is a costly consequence of undetected adverse effects or toxicity. Over 30% of such withdrawals are due to cardiac toxicity (pro-arrhythmic effects mediated by cardiac ion channels), therefore regulatory agreements mandate the testing of all new drugs for cardiac liability.
GW researchers developed the first...
Published: 5/12/2026
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Inventor(s): Emilia Entcheva, Aleksandra Klimas
Keywords(s):
Category(s): Technology Classifications > Research Tools > Drug Screening
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