Heart disease is among the most challenging human diseases to diagnose and treat, and it remains the leading cause of mortality worldwide. Its complex underlying pathophysiology has driven the development of advanced techniques to study heart function during sinus rhythm, dysfunction, and treatment. There is growing interest in combining electrical and optical approaches for multiparametric studying cardiac physiology and disease conditions from the same myocardial sites, particularly in vivo, to verify experimental hypotheses, generate important insights into arrhythmogenic drivers.
GW and Northwestern University researchers have developed a novel cardiac sensing platform that simultaneously maps multiple parameters that govern cardiac (patho)physiology from beating hearts in vivo, functioning with a wireless interface. The device shows excellent biocompatibility and records the fluorescence of calcium reporter with performance comparable to imaging cameras. Multiparametric in vivo mapping of electrical excitation, calcium dynamics, and their combined effects on cardiac excitation-contraction coupling is demonstrated during normal rhythm, arrhythmia, and treatment.
Fig. Soft multimodal optoelectronic array device for multiparametric electrical and optical mapping of cardiac physiology.
Applications:
- Cardiac research to support scientific discoveries.
- Advance clinical life-saving diagnostics and therapies.
Advantages:
- Excellent mechanical flexibility
- Compatible with Bluetooth wireless operation
- Low electrochemical impedance
