Search Results - alberto+bosque-pardos

2 Results

Sort By:

Small Molecule Modulators of PTPN1/2 for Broad-Spectrum Solid Tumor Therapy

Solid tumors represent over 90% of adult cancers and remain notoriously difficult to treat. Current therapies, including chemotherapy, epigenetic drugs, and checkpoint inhibitors, face serious limitations: tumor genetic heterogeneity drives relapse, immunosuppressive microenvironments block immune infiltration, and resistance mechanisms undermine durable...

Published: 5/12/2026 | Inventor(s): Alberto Bosque-Pardos

Keywords(s):

Category(s): Technology Classifications > Therapeutics > Small Molecules

In vitro drug treatment to proliferate and activate effector cells for immunotherapy

STAT5 SUMOylation inhibition increases CD4 and CD8 T-cell proliferation and and production of immune effector molecules in CD8 T-cells and NK (natural killer) cells. Both attributes address critical limiting factors in applying cell therapies to fighting cancers and pathogens. The difficulty of obtaining enough activated effector cells limits the efficacy...

Published: 5/12/2026 | Inventor(s): Alberto Bosque-Pardos, Amanda Beatriz Rodrigues Barreto de Macedo, Eric Sorensen, Vicente Planelles

Keywords(s):

Category(s): Technology Classifications > Therapeutics > Small Molecules