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Small Molecule Modulators of PTPN1/2 for Broad-Spectrum Solid Tumor Therapy
Solid tumors represent over 90% of adult cancers and remain notoriously difficult to treat. Current therapies, including chemotherapy, epigenetic drugs, and checkpoint inhibitors, face serious limitations: tumor genetic heterogeneity drives relapse, immunosuppressive microenvironments block immune infiltration, and resistance mechanisms undermine durable...
Published: 1/9/2026
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Inventor(s): Alberto Bosque-Pardos
Keywords(s):
Category(s): Technology Classifications > Therapeutics > Small Molecules
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Transformative Nanoparticle-Based Therapy for HIV
HIV/AIDS remains a persistent global epidemic, affecting thousands of new individuals annually. A critical challenge in HIV treatment is the virus's ability to lie dormant in infected T cells, evading immune responses and existing antiretroviral therapies (ART). This latent HIV can reactivate unpredictably, leading to viral rebound and disease progression.
Dr....
Published: 1/9/2026
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Inventor(s): Rohan Fernandes, Preethi Balakrishnan, Anvitha Shri Ramanujam, Alberto Bosque-Pardos, Indra Sarabia, Carissa Holmberg
Keywords(s):
Category(s): Technology Classifications > Therapeutics > Nanoparticles, Technology Classifications, Technology Classifications > Research Tools > Drug Screening
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In vitro drug treatment to proliferate and activate effector cells for immunotherapy
STAT5 SUMOylation inhibition increases CD4 and CD8 T-cell proliferation and and production of immune effector molecules in CD8 T-cells and NK (natural killer) cells. Both attributes address critical limiting factors in applying cell therapies to fighting cancers and pathogens. The difficulty of obtaining enough activated effector cells limits the efficacy...
Published: 1/9/2026
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Inventor(s): Alberto Bosque-Pardos, Amanda Beatriz Rodrigues Barreto de Macedo, Eric Sorensen, Vicente Planelles
Keywords(s):
Category(s): Technology Classifications > Therapeutics > Small Molecules
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