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Combating Opioid-Induced Respiratory Depression Using Setmelanotide

The opioid crisis is a serious public health crisis in the United States. Mortality from opioid overdose increased by roughly ten times from 1999 to 2021. The primary cause of death is due to opioid-induced respiratory depression (OIRD). Currently, Naloxone and Nalmefene are actively used to reverse OIRD in emergency settings and by first responders....

Published: 2/18/2025 | Inventor(s): Vsevolod Polotsky, David Mendelowitz, O Aung, Mateus Ramos Amorim, Joan Escobar

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Category(s): Technology Classifications > Therapeutics > Small Molecules, Technology Classifications > Therapeutics > Repurposed Drugs

Oxytocin reverses respiratory depression induced by xylazine-laced fentanyl

The opioid crisis is a serious public health issue in the United States. Synthetic opioids such as fentanyl have contributed significantly to this crisis. However, recent samples have shown the presence of xylazine, a veterinary tranquilizer, with fentanyl. Xylazine was found in almost 80% of fentanyl samples in Maryland between 2021 and 2022. Naloxone...

Published: 2/18/2025 | Inventor(s): Joan Escobar, Olga dergacheva, David Mendelowitz

Keywords(s):

Category(s): Technology Classifications > Therapeutics, Technology Classifications > Therapeutics > Repurposed Drugs