Search Results - vsevolod+polotsky

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Combating Opioid-Induced Respiratory Depression Using Setmelanotide

The opioid crisis is a serious public health crisis in the United States. Mortality from opioid overdose increased by roughly ten times from 1999 to 2021. The primary cause of death is due to opioid-induced respiratory depression (OIRD). Currently, Naloxone and Nalmefene are actively used to reverse OIRD in emergency settings and by first responders....

Published: 2/18/2025 | Inventor(s): Vsevolod Polotsky, David Mendelowitz, O Aung, Mateus Ramos Amorim, Joan Escobar

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Category(s): Technology Classifications > Therapeutics > Small Molecules, Technology Classifications > Therapeutics > Repurposed Drugs

Intranasal leptin to treat opioid-induced respiratory depression (OIRD) in obese patients

Respiratory depression is the leading cause of morbidity and mortality associated with opioids. Patients with obesity experience pain and need opioids more frequently than normal-weight individuals. Chronic consumption of opioids is associated with addiction, physical dependence, and tolerance. Tolerance leads to requirement of higher doses of opioids...

Published: 2/18/2025 | Inventor(s): David Mendelowitz, Vsevolod Polotsky, Carla Freire

Keywords(s):

Category(s): Technology Classifications > Therapeutics