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HDAC6i-Activated Macrophage Cell Therapy
The tumor microenvironment (TME) plays a key role in tumor growth and survival. Often the immunosuppressive nature of the TME prevents success of treatments including immune checkpoint blockade (ICB), radiation therapy (RT), and chemotherapy. Macrophages in the TME contribute to its immunosuppressive or immunostimulatory character. M2 macrophages secrete...
Published: 2/18/2025
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Inventor(s): Alejandro Villagra, Nima Aghdam, Satish kumar Noonepalle
Keywords(s):
Category(s): Technology Classifications > Therapeutics > Cells
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STAT-Activated Macrophages for Targeted Cancer Immunotherapy
Macrophages play a critical role in both innate and adaptive immunity, essential for maintaining tissue homeostasis and combating infections. In the context of cancer, macrophages can differentiate into two main phenotypes: M1 macrophages, which exhibit anti-tumor properties, and M2 macrophages, which support tumor progression and contribute to anti-inflammatory...
Published: 2/18/2025
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Inventor(s): Alejandro Villagra, Satish kumar Noonepalle, Maria del Mar Gracia Hernandez
Keywords(s):
Category(s): Technology Classifications > Therapeutics > Cells
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Anti-inflammatory adoptive cell therapy using macrophages for enhanced tissue regeneration and wound healing
Patients dealing with organ transplants, autoimmune disorders, chronic wounds, ischemic injury, and other diseases that trigger inflammatory processes often lack effective treatment strategies. Macrophages are key cellular components of innate immunity with varying impacts on inflammation. M1 macrophages are pro-inflammatory, while M2 macrophages are...
Published: 2/18/2025
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Inventor(s): Alejandro Villagra, Satish kumar Noonepalle, Maria del Mar Gracia Hernandez, Brett Shook
Keywords(s):
Category(s): Technology Classifications > Therapeutics > Small Molecules
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