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A Novel Selective HDAC11 Inhibitor with Broad Anti-Cancer Efficacy
HDAC11 is a Histone Deacetylase (HDAC) enzyme. However, HDAC11 has a high defatty-acylase activity while its deacetylation activity is virtually nonexistent, which is linked to poor prognosis in multiple cancers. This suggests that inhibition of HDAC11 can be used to treat cancers by modulating protein function. No potent and selective inhibitors for...
Published: 3/13/2025
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Inventor(s): Edward Seto, Hening Lin
Keywords(s):
Category(s): Technology Classifications > Therapeutics
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Small molecule inhibitor of ARID4B to combat endocrine therapy resistance in breast cancer
Large-scale genomic analyses, including data from The Cancer Genome Atlas (TCGA) and other breast cancer datasets, have identified amplification of the AT-rich interactive domain 4B (ARID4B) protein, also known as retinoblastoma binding protein 1-like 1 (RBP1L1), in approximately 22% of human breast cancer cases. Compelling clinical evidence highlights...
Published: 2/18/2025
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Inventor(s): Samuel Awuah, Mei-Yi Wu, Ray-Chang Wu, Samuel Ofori
Keywords(s):
Category(s): Technology Classifications, Technology Classifications > Therapeutics
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Probiotics to treat or prevent gut colonization by drug-resistant E. Coli
Antibiotic-resistant bacteria threaten public health worldwide. One of the most widespread strains is Escherichia coli sequence type 131, which has a subclone lineage called H30R that is resistant to fluoroquinolones. This subtype, known as ST131-H30R, causes a large number of E. Coli infections that are resistant to antimicrobial treatment. The bacteria...
Published: 2/18/2025
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Inventor(s): Cindy Liu, Daniel Park, Lance Price, James Johnson
Keywords(s):
Category(s): Technology Classifications > Therapeutics
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Oxytocin reverses respiratory depression induced by xylazine-laced fentanyl
The opioid crisis is a serious public health issue in the United States. Synthetic opioids such as fentanyl have contributed significantly to this crisis. However, recent samples have shown the presence of xylazine, a veterinary tranquilizer, with fentanyl. Xylazine was found in almost 80% of fentanyl samples in Maryland between 2021 and 2022. Naloxone...
Published: 2/18/2025
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Inventor(s): Joan Escobar, Olga dergacheva, David Mendelowitz
Keywords(s):
Category(s): Technology Classifications > Therapeutics, Technology Classifications > Therapeutics > Repurposed Drugs
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Magnetically Enhanced Plasma Treatment of Cancer
Previously, GW researchers invented a method to selectively kill cancer cells with cold atmospheric plasma (CAP), while leaving neighboring normal cells unaffected. In the present invention, the researchers devised an enhanced method for CAP cancer therapy by concurrently exposing the cancer cells to a static magnetic field (Fig. 1).
The researchers...
Published: 2/18/2025
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Inventor(s): Michael Keidar, Xiaoqian Cheng, Alexey Shashurin, Jonathan Sherman
Keywords(s):
Category(s): Technology Classifications > Therapeutics > Cells, Technology Classifications > Therapeutics
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Intranasal leptin to treat opioid-induced respiratory depression (OIRD) in obese patients
Respiratory depression is the leading cause of morbidity and mortality associated with opioids. Patients with obesity experience pain and need opioids more frequently than normal-weight individuals. Chronic consumption of opioids is associated with addiction, physical dependence, and tolerance. Tolerance leads to requirement of higher doses of opioids...
Published: 2/18/2025
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Inventor(s): David Mendelowitz, Vsevolod Polotsky, Carla Freire
Keywords(s):
Category(s): Technology Classifications > Therapeutics
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Cold atmospheric plasma-stimulated media for treating cancers
For successful cancer therapy, the most important aspect is selective eradication of cancer cells without damaging healthy cells. Cancer cells and normal cells have different thresholds for tolerance of reactive oxygen species (ROS) and reactive nitrogen species (RNS) before cell death (apoptosis) is induced. Previously, GW researchers invented a cold...
Published: 2/18/2025
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Inventor(s): Michael Keidar, Zhitong Chen, Xiaoqian Cheng, Li Lin
Keywords(s):
Category(s): Technology Classifications > Therapeutics > Cells, Technology Classifications > Therapeutics
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Optimization of Cold Atmospheric Plasma-Stimulated Media for Treatment of Cancer
Previously, GW researchers invented a method to selectively kill cancer cells with cold atmospheric plasma (CAP) while leaving neighboring normal cells intact. In a subsequent study, the researchers showed that similar anti-cancer effects can be achieved indirectly using CAP-stimulated media (CAPSM). Stability of CAPSM (preservation of its anti-cancer...
Published: 2/18/2025
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Inventor(s): Dayun Yan, Michael Keidar, Jonathan Sherman
Keywords(s):
Category(s): Technology Classifications > Therapeutics > Cells, Technology Classifications > Therapeutics > Proteins and Peptides, Technology Classifications > Therapeutics
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3D printed vascularized tissue scaffold with extracellular matrix triggered growth factor release
Vas-Scaf” is a 3D bio-printed vascularized bone scaffold perfused with osteogenic and angiogenic growth factors. Artificial bone grafts lacking vascularization fail due to poor integration of new tissues with the host and death of interior bone tissues. Bone and blood vessel tissues require different support structures and different biochemical...
Published: 2/18/2025
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Inventor(s): Haitao Cui, Wei Zhu, Benjamin Holmes, Lijie Zhang
Keywords(s):
Category(s): Technology Classifications > Therapeutics, Technology Classifications > Therapeutics > Nanoparticles, Technology Classifications > Industrial or Consumer Tech > Materials
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A new small molecule to kill drug-resistant malaria parasites
GW researchers synthesized the new small molecule, RCB-185, and initially showed efficacy against Mycobacterium tuberculosis (Mtb), but now demonstrate much higher efficacy against malaria. According to the World Health Organization, 2015 had 212 million cases of malaria with 429,000 deaths. People desperately need new treatments for malaria, as use...
Published: 2/18/2025
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Inventor(s): Cynthia Dowd, Robert Brothers, Audrey Odom, Rachel Edwards
Keywords(s):
Category(s): Technology Classifications > Therapeutics, Technology Classifications > Therapeutics > Small Molecules
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